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Prajapati, P. K.
- Anti-Arthritic Activity of Dashanga Ghana (An Ayurvedic Compound Formulation) against Freund’s Adjuvant Induced Arthritis in Charles Foster Albino Rats
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Authors
Affiliations
1 Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, IN
2 Drug Discovery Group, R&D Centre, The Himalaya Drug Company, Makali, Bangalore, IN
3 SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, IN
1 Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, IN
2 Drug Discovery Group, R&D Centre, The Himalaya Drug Company, Makali, Bangalore, IN
3 SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 1 (2015), Pagination: 141-146Abstract
Introduction: Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases. There is a need to investigate the complete therapeutic potential of these herbals for providing newer and safer treatment options with minimum side effects. Considering this, a polyherbal Ayurvedic compound formulation (Dashanga Ghana) has been studied in experimental animals to evaluate anti-arthritic activity. Materials and Methods: Dashanga Ghana has been prepared in the laboratory by following standard guidelines. Charles Foster albino rats were used to evaluate the activity through Freund’s adjuvant induced arthritis model. Results and Conclusions: Dashanga Ghana is found to possess significant anti-arthritic activity. Further studies are required to identify and characterize exact active phyto-constituents and to elucidate the exact mechanism of action, which is responsible for the observed pharmacological profile.Keywords
Arthritis, Ayurveda, Dashanga Ghana, Freund’s Adjuvant, Paw Oedema.
- Effect of Indian Traditional Medicine:Makaradhwaja on Biochemical Parameters in Streptozotocin Induced Diabetic Albino Rats
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Authors
Affiliations
1 Dept. of RS & BK, SSAM & H, MUHS, Nashik, IN
2 Central Ayurveda Drug Research Institute for Drug Development, Kolkata, IN
3 Dept. of RS & BK, All India Institute of Ayurveda, New Delhi, IN
4 Dean, All India Institute of Ayurveda, New Delhi, IN
1 Dept. of RS & BK, SSAM & H, MUHS, Nashik, IN
2 Central Ayurveda Drug Research Institute for Drug Development, Kolkata, IN
3 Dept. of RS & BK, All India Institute of Ayurveda, New Delhi, IN
4 Dean, All India Institute of Ayurveda, New Delhi, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 1 (2016), Pagination: 33-37Abstract
Use of metallic preparations has raised safety concerns and debate in scientific community for containing considerable levels of heavy metals like lead, mercury and/or arsenic etc. Such controversies have tried to malign the reputation of Ayurveda at global levels. Makaradhwaja, one such metallic preparation is frequently being used in many conditions. But, its safety at the levels of ponderal and biochemical parameters is not reported. Considering this, the present study is planned to evaluate safety effect of Triguna Balijarita Makaradhwaja (TBM) and Shadguna Balijarita Makaradhwaja (SBM) in wistar strain albino rats. TBM and SBM were prepared by following classical guidelines. Animals were divided into four groups. TBM and SBM were administered to rats at the doses of 2.63mg/kg along with Guduchi Ghana and honey for 21 days. Blood samples were collected and animals were sacrificed on 22nd day. Ponderal and biochemical parameters were studied. The results showed insignificant changes in the body weight, Serum creatinine, Cholesterol, Triglyceride and HDL; while SGOT, SGPT and Blood urea were decreased significantly by the treatment of TBM and SBM. The findings of the present study suggests that Makaradhwaja in therapeutic doses along with Honey administered to rats for 21 days does not have appreciable toxicological effects on ponderal and biochemical parameters.Keywords
Makaradhwaja, Mercuric Sulphide, Metallic Preparations, Safety, Toxicity.References
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- Omotayo OE, Siti AS, Mohd W. Honey - A Novel Antidiabetic Agent. Int Journal biological sciences 2012; 8(6):913934.
- Kumar G, Srivastava A, Sharma SK, Gupta YK. Safety evaluation of an Ayurvedic medicine - Arogyavardhini vati on brain, liver and kidney in rats. J Ethnopharmaco 2012;140:151-60
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- Kumar G, Srivastava A, Sharma SK, Gupta YK. Safety evaluation of mercury based Ayurvedic formulation (Sidh Makardhwaj) on brain cerebrum, liver & kidney in rats. Indian J Med Res 2014;139:610-8
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- Hore P, Ahmed M, Ehrlich J, Steffen L, Sedlar S. Lead Poisoning in Pregnant Women Who Used Ayurvedic Medications from India - New York City. 2011–2012, Centre for Disease Control and Prevention (Morbidity and Mortality Weekly Report), 61 (33):24, 2012
- Sathe K, Ali U, Ohri A. Acute renal failure secondary to ingestion of ayurvedic medicine containing mercury. Indian J Nephrol 2013; 23:301-3.
- Khedekar S, Patgiri BJ, Ravishankar B, Prajapati PK. Standard manufacturing process of Makaradhwaja prepared by Swarna Patra-Varkha and Bhasma. Ayu 2011;32:109-15.
- Khedekar S, Prajapati P K, Standard Manufacturing process of Shadguna Balijarita Makaradhwaja, Ayu 2014:35; 428-32 17. Sanjay Khedekar, B Ravishankar, PK Prajapati. Role of Gandhaka Jarana in the preparation of Makaradhwaja; (PhD Thesis), IPGT & RA, Gujarat Ayurved University, Jamnagar; 2012
- Akbarzadeh A, Norouzian D, Mehrabi M, Jamshidi S, Farhangi A, Verdi A, Mofidian S, Rad B. Induction of diabetes by Streptozotocin in rats. Indian J Clin Biochem. 2007 Sep; 22(2): 60–64.
- Khedekar S, Patgiri BJ, Ravishankar B, Prajapati PK. Antihyperglycemic effect of makaradhwaja on streptozotacin induced diabetes in rats. J Glob Pharma Tech 2012;4:16-24.
- Charde R, Sharma R, Patgiri BJ, Prajapati PK. Efficacy of Makaradhwaja on Madhumeha (Type2 Diabetes) – A Review through Ayurvedic Studies. Amer J of Phytom Clini Thera 2014; 2(12):1470-79
- Khedekar S, Prajapati P, Patgiri B, Galib R. A scientific review of gold containing herbo-mineral preparation : Makaradhwaja. Green Pharm 2015; 9(4):S7-11.
- Von Berg R, Greenwood MR, editors. 18. Mercury: Metal and their compound in environment. New York: VCH Publisher Inc; 1991. p. 1045-8.
- El-Shenawy SM, Hassan NS. Comparative evaluation of the 19 protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol Rep 2008; 60 : 199-208.
- Khedekar S, Galib R, Ravishankar B, Prajapati P. Anti-diabetic activity of traditional Indian gold containing preparation: Shadguna Balijarita Makaradhwaja on streptozotocin induced diabetic rats. J Intercult Ethnopharmacol 2016; 5(2):162-167.
- Ginsberg H. Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes 1996,45 suppl 3.S27-30.
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- Khedekar S, Galib R, Patgiri B, Ravishankar B, Prajapati PK, Antidiabetic activity of dried extract of Tinospora cordifolia (Guduchi Ghana) and honey in streptozotacine induced diabetic rats. Green Pharm 2015; 9(4):S31-37.
- Assessment of Genotoxic Potential of Hridayarnava Rasa (A Herbo‑Mineralo‑Metallic Ayurvedic Formulation) Using Chromosomal Aberration and Sperm Abnormality Assays
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Authors
Chandrashekhar Y. Jagtap
1,
Swapnil Y. Chaudhari
2,
Jalaram H. Thakkar
3,
R. Galib
2,
P. K. Prajapati
2
Affiliations
1 Departments of Rasashastra and Bhaishajya Kalpana, Parul Institute of Ayurveda, Limda, Vadodara, IN
2 Rasashastra and Bhaishajya Kalpana, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, IN
3 Department of Pharmacology, Swargiy Sanjibhai Roopajibhai College of Pharmacy, Silvassa, Union Territory of Dadra and Nagar Haveli, IN
1 Departments of Rasashastra and Bhaishajya Kalpana, Parul Institute of Ayurveda, Limda, Vadodara, IN
2 Rasashastra and Bhaishajya Kalpana, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, IN
3 Department of Pharmacology, Swargiy Sanjibhai Roopajibhai College of Pharmacy, Silvassa, Union Territory of Dadra and Nagar Haveli, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 21, No 3 (2014), Pagination: 242-247Abstract
Objectives: Herbo‑mineral formulations are being successfully used in therapeutics since centuries. But recently, they came under the scanner for their metallic contents especially the presence of heavy metals. Hence it is the need of the hour to assess and establish the safety of these formulations through toxicity studies. In line with the various toxicity studies that are being carried out, Government of India expressed the need for conducting genotoxicity studies of different metal‑ or mineral‑based drugs. Till date very few Ayurvedic herbo‑mineral formulations have been studied for their genotoxic potential. The present study is aimed to evaluate the genotoxic potential of Hridayarnava Rasa. Materials and Methods: It was prepared as per classical guidelines and administered to Swiss albino mice for 14 consecutive days. Chromosomal aberration and sperm abnormality assay were done to evaluate the genotoxic potential of the test drugs. Cyclophosphamide (CP) was taken as positive group and results were compared. Results: All treated groups exhibited significant body weight gain in comparison to CP group. Results revealed no structural deformity in the above parameters in comparison to the CP‑treated group. Conclusion: Reported data showed that both tested samples of Hridayarnava Rasa does not possess genotoxic potential under the experimental conditions and can be safely used.Keywords
Colchicine, cyclophosphamide, genotoxicity, herbo‑mineral formulations, Tamra bhasma- Effect of Shodhana Treatment on Chronic Toxicity and Recovery of Aconite
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